Details
Question
- What is the clinical effectiveness of systemic thrombolysis combined with EVT compared to EVT alone in patients with large vessel occlusion acute ischemic stroke?
Key Message
Evidence was mixed, with higher-quality evidence suggesting that there were no differences between treatment with alteplase before endovascular therapy or endovascular therapy alone in patients with large vessel occlusion acute ischemic stroke for outcomes related to safety and efficacy, and lower-quality evidence indicating a difference between the groups for certain outcomes.