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Tisagenlecleucel (Kymriah) for Pediatric Acute Lymphoblastic Leukemia and Diffuse Large B-Cell Lymphoma

Last updated: January 15, 2019
Project Number: OP0538-000 / CT0001
Product Line: Optimal Use
Result type: Report

Tisagenlecleucel is a chimeric antigen receptor (CAR) T-cell therapy for the treatment of adults with relapsed or refractory diffuse large B-cell lymphoma and children and young adults with relapsed or refractory acute lymphoblastic leukemia.

CADTH undertook a review of manufacturer-submitted materials and published literature to assess the clinical impact, cost-effectiveness, and implementation considerations, including patient and caregiver perspectives and experiences, ethical considerations, and other considerations, such as facilities for the administration of CAR T-cell therapy, therapy eligibility, travel requirements, and resource costs associated with the provision of tisagenlecleucel therapy in Canada.

The project has following key components:

  • protocols
  • clinical systematic review
  • economic review
  • review of implementation considerations, ethics, and patient and caregiver perspectives and experiences
  • recommendations report.

Read more about CAR T-cell therapy reviews at CADTH.