What are the evidence-based guidelines regarding the management of sexual dysfunction associated with psychotropic medications?
For antipsychotic-related sexual dysfunction, 1 guideline recommends switching to aripiprazole or another non-hyperprolactinemic antipsychotic as the first option. Alternatively, the guideline recommends adjunctive treatment with aripiprazole, or switching to antipsychotics that have less impact on sexual function. Another guideline recommends adding estrogen or testosterone treatment to the antipsychotic medication to assist sexual dysfunction in women.
For antidepressant-related sexual dysfunction, 1 guideline recommends switching to agomelatine or to a non-serotonergic drug or fluvoxamine as first option. Alternatively, the guideline recommends switching to a partially non-serotonergic antidepressant, adding antidotes, or using vaginal lubricants.