Tuberculosis in People with Compromised Immunity: A Review of Guidelines


( Last Updated : March 18, 2020)
Project Line:
Health Technology Review
Project Sub Line:
Summary with Critical Appraisal
Project Number:
RC1238-000

Details


Question


  1. What are the evidence-based guidelines for the prevention, identification, or treatment of tuberculosis in people with compromised immunity?


Key Message

Twenty evidence-based guidelines for the prevention, identification, or treatment of TB were identified and included in this report. Four guidelines made recommendations regarding the prevention of TB in patients with compromised immunity. Twelve guidelines made recommendations regarding the identification of LTBI and nine guidelines made recommendations regarding the identification of active TB disease in patients with compromised immunity. For the treatment of TB in patients with compromised immunity, ten guidelines made recommendations regarding the treatment of LTBI and ten guidelines made recommendations regarding the treatment of active TB disease.Overall, there are seven high-quality, one moderate-quality, and twelve low-quality guidelines that include between one and 47 recommendations on TB in patients with compromised immunity. The recommendations vary in strength and the quality of the evidence, as well as the population of interest. The population and topic of interest may determine which guideline(s) and which recommendation(s) are of interest.