Intraosseous Contrast Media Injection for Computed Tomography Scan or Magnetic Resonance Imaging: A Review of Clinical Effectiveness and Guidelines


( Last Updated : February 24, 2020)
Project Status:
Completed
Project Line:
Health Technology Review
Project Sub Line:
Summary with Critical Appraisal
Project Number:
RC1234-000

Details


Question


  1. What is the comparative clinical effectiveness of intraosseous contrast media injection versus intravenous contrast media injection for patients undergoing computed tomography scan or magnetic resonance imaging?

  2. What are the evidence-based guidelines regarding the use of intraosseous contrast media injection for patients undergoing computed tomography scan or magnetic resonance imaging?


Key Message

One relevant non-randomized study was identified regarding the comparative clinical effectiveness of intraosseous contrast media injection versus intravenous contrast media injection for patients undergoing computed tomography scan. No relevant evidence-based guidelines were identified.



Although the study found no difference in objective and subjective computed tomography image quality between intraosseous and intravenous contrast media delivery, it remains uncertain whether the findings are reliable given that the study was likely not adequately powered nor reflective of the larger clinical population.



The limitations of the included study, such as lack of blinding to treatment, inadequate comprehensiveness of post-interventional complications reporting, small sample size, and disproportionate gender balance, should be considered when interpreting the results.