Oral Rehydration Solutions versus Drink of Choice in Children with Dehydration: A Review of Clinical Effectiveness


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Project Line:
Health Technology Review
Project Sub Line:
Summary with Critical Appraisal
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  1. What is the comparative clinical effectiveness of oral rehydration solution versus other fluids of choice for pediatric patients with, or at risk of, dehydration?

Key Message

​One relevant randomized controlled trial was identified regarding the clinical effectiveness of half-strength apple juice followed by preferred fluids versus a commercially available electrolyte maintenance solution in pediatric patients with minimal dehydration secondary to gastroenteritis. Overall, half-strength apple juice followed by preferred fluids were found to be both non-inferior and superior to the electrolyte maintenance solution in the primary composite outcome of overall treatment failure. However, the results of this trial should be interpreted with caution as several limitations were identified. The authors of the trial concluded that dilute apple juice followed by preferred fluids may be an alternative to electrolyte maintenance solutions.