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Primary Care Initiated Gender-Affirming Therapy for Gender Dysphoria: A Review of Evidence Based Guidelines

Last updated: May 1, 2020
Project Number: RC1267-000
Product Line: Rapid Response
Research Type: Devices and Systems
Report Type: Summary with Critical Appraisal
Result type: Report


  1. What are the evidence-based guidelines regarding primary care initiated gender-affirming therapy in adults with gender dysphoria?

Key Message

​One evidence-baseline clinical practice guideline was identified that provides guidance for the health of transsexual, transgender and gender-nonconforming people. The guideline suggests that with appropriate training, hormone therapy can be managed by a variety of healthcare providers, including primary care providers such as primary physician or nursing practitioner. However, the recommendations did not specify whether this treatment can be initiated by primary care providers. The quality of this guideline was limited due to insufficient reporting on searching for evidence and formulating the recommendations. This guideline did not report the strength of recommendations or the quality of the evidence.