Evidence to Use in Primary Care
If you're looking for independent, evidence-based information on common issues in primary care and clinical practice, you’ll find it here. You may also wish to visit our Evidence Bundles on diabetes, pain, opioids, medical cannabis, and mental health.
We’ve selected the following materials to get you started:
- Virtual Care Use in Primary Care or Specialty Care Settings (Rapid Review, August 17, 2022)
- Improving Access to Primary Care in Canada (Environmental Scan, July 19, 2022)
- Melatonin for the Treatment of Insomnia in Children and Adolescents (Rapid Review, June 10, 2022)
- Intranasal Glucagon for the Treatment of Hypoglycemia (Rapid Review, June 24, 2022)
- Vitamin B12 Testing in People with Suspected Vitamin B12 Deficiency (Rapid Review, March 24, 2022)
- Evaluating the Credibility of Health Websites: Can You Trust Dr. Google?(Tools, March 25, 2020)
- Tips and resources for determining whether a health website contains reliable health information.
In this Bundle
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Interventions for the Treatment or Management of Lyme Disease: Clinical Effectiveness and Guidelines
(Reference List, July 16, 2019)
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Interventions for the Diagnosis of Lyme Disease: Clinical Effectiveness and Guidelines
(Reference List, July 12, 2019)
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One Dose of Doxycycline for the Prevention of Lyme Disease: A Review of Clinical Effectiveness and Guidelines
(Summary with Critical Appraisal, May 21, 2019)
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Detection and Diagnosis of Sepsis in Rural and Remote Areas: An Environmental Scan
(Environmental Scan, January 9, 2019)
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Optimal Strategies for the Diagnosis of Acute Pulmonary Embolism
Short on time? Read the In Brief
(Optimal Use, March 1, 2018) -
Recognition and Diagnosis of Sepsis in Adults: Evidence-Based Guidelines
(Summary of Abstracts, January 24, 2018)
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Early Mobilization for Patients with Venous Thromboembolism: A Review of Clinical Effectiveness and Guidelines
(Summary with Critical Appraisal, January 17, 2018)
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Frequency of Prothrombin Time and International Normalized Ratio Testing: Guidelines
(Summary of Abstracts, January 17, 2018)
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Compression Garments for People With Venous Leg Ulcers
(Reference List, December 15, 2021)
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Acetylsalicylic Acid for Primary Prevention of Cardiovascular Events: Clinical Effectiveness and Guidelines
(Summary of Abstracts, August 19, 2019)
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Dual Antiplatelet Therapy Following Percutaneous Coronary Intervention: Clinical and Economic Impact of Standard Versus Extended Duration
Short on time? Read the In Brief
(Optimal Use, April 4, 2019) -
Decisions Regarding Treatments for the Secondary Prevention of Heart Disease: Patient Experiences
(Reference List, October 31, 2018)
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Appropriate Pharmacotherapy for Inflammatory Bowel Disease
(Technology Review, June 6, 2019)
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Probiotics for Antibiotic-Associated Diarrhea in Pediatrics: A Review of Clinical Effectiveness and Guidelines
(Summary with Critical Appraisal, March 25, 2019)
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Biologics Dose Escalation for the Treatment of Inflammatory Bowel Disease: A Review of Clinical Effectiveness, Cost-Effectiveness, and Guidelines
(Summary with Critical Appraisal, August 28, 2018)
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Non-Pharmacological Alternatives to Proton Pump Inhibitors: Comparative Clinical Effectiveness and Guidelines
(Summary of Abstracts, May 11, 2018)
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Therapeutic Drug Monitoring for Patients with Inflammatory Bowel Disease: Clinical Effectiveness and Guidelines
(Summary of Abstracts, April 6, 2018)
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Prucalopride for Gastrointestinal Motility Disorders: A Review of Clinical Effectiveness
(Summary with Critical Appraisal, December 6, 2017)
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Sound Masking Devices for Tinnitus in People Without Hearing Loss
(Summary of Abstracts, October 28, 2021)
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Non-Invasive Bone Conduction Devices for Conductive Hearing Loss: Clinical Effectiveness, Cost-Effectiveness, and Guidelines
(Summary of Abstracts, November 12, 2019)
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Interventions That Produce Residual Inhibition for the Treatment of Tinnitus: Clinical Effectiveness and Guidelines
(Summary of Abstracts, May 30, 2019)
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Real-Time Continuous Glucose Monitoring for People Living With Type 1 Diabetes
(Rapid Review, August 22, 2022)
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Intermittently Scanned and Real-Time Continuous Glucose Monitoring for People With Diabetes
(Rapid Review, July 6, 2022)
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Intranasal Glucagon for the Treatment of Hypoglycemia
(Summary with Critical Appraisal, June 24, 2022)
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Vitamin B12 Testing in People with Suspected Vitamin B12 Deficiency
(Rapid Review, March 24, 2022)
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Hybrid Closed-Loop Insulin Delivery Systems for People with Type 1 Diabetes
(Optimal Use, June 23, 2021)
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Behavior-based Primary-Care Interventions for the Prevention of Overweight and Obesity in Children
(Reference List, April 9, 2021)
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Flash Glucose Monitoring Systems in Pediatric Populations with Diabetes
(Summary with Critical Appraisal, April 6, 2021)
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Electronic Food Assessments for People With Diabetes
(Summary of Abstracts, January 13, 2021)
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Flash Glucose Monitoring System FreeStyle Libre to Monitor Glycemia in Patients With Diabetes
(Technology Review, September 24, 2020)
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Pioglitazone for Type 2 Diabetes Mellitus and Pre-Diabetes: A Review of Safety
(Summary with Critical Appraisal, June 22, 2020)
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Vitamin D Supplementation for the Prevention of Tuberculosis Infection: Clinical Effectiveness and Guidelines
(Summary of Abstracts, March 31, 2020)
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Islet Cell Transplantation for Patients with Unstable or Uncontrollable Diabetes Mellitus: Clinical Effectiveness, Cost-Effectiveness and Guidelines
(Reference List, March 18, 2020)
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Ozurdex for Diabetic Macular Edema: Clinical Effectiveness, Cost-effectiveness, and Guidelines
(Reference List, March 9, 2020)
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Prescriptive Nutritional Guidance for Prevention of Cancer: Guidelines
(Summary of Abstracts, February 26, 2020)
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Preventative Foot Care for Patients with Diabetes: A Review of Clinical Effectiveness and Cost-Effectiveness
(Summary with Critical Appraisal, November 20, 2019)
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Intermittent Fasting for Adults with Type 2 Diabetes: A Review of the Clinical Effectiveness and Guidelines
(Summary with Critical Appraisal, November 13, 2019)
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Low Carbohydrate Diets for Diabetes: A Review of the Clinical Effectiveness and Guidelines
(Summary with Critical Appraisal, October 31, 2019)
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Sodium-Glucose Cotransporter 2 Inhibitors for the Treatment of Diabetic Nephropathy: A Review of Clinical Effectiveness
(Summary with Critical Appraisal, September 20, 2019)
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Hybrid Closed Loop Insulin Delivery Systems: Clinical Effectiveness
(Summary of Abstracts, September 17, 2019)
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Standardized Insulin Order Sets for Insulin-Dependent Diabetic Adults in the Community Setting: Clinical Evidence and Guidelines
(Reference List, May 10, 2019)
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Oral Glucose Tablets versus Gel or Solution for the Treatment of Mild Hypoglycemia: Comparative Clinical Effectiveness
(Summary of Abstracts, May 8, 2019)
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Intravenous Dextrose Drip versus Push for Adults Experiencing Hypoglycemia: Comparative Clinical Effectiveness
(Summary of Abstracts, May 6, 2019)
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Long-Acting Insulin Analogues versus Human NPH Insulin for Adults with Type 2 Diabetes and Unresponsive to Non-insulin Therapies: Clinical Effectiveness, Cost-Effectiveness, and Guidelines
(Summary of Abstracts, May 3, 2019)
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Vitamin D Supplementation for the Prevention of Falls and Fractures in Residents of Long-Term Care Facilities: A Review of Clinical Effectiveness, Cost-Effectiveness, and Guidelines
(Summary with Critical Appraisal, April 30, 2019)
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Non-Insulin Therapies versus Prandial Insulin for Adults with Type 2 Diabetes: Clinical Effectiveness, Cost-Effectiveness, and Guidelines
(Summary of Abstracts, April 24, 2019)
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Interventions for Malnutrition in Seniors: A Review of Clinical Effectiveness
(Summary with Critical Appraisal, January 3, 2019)
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Continuous Glucose Monitoring for Patients with All Diabetes Types: Clinical Effectiveness and Guidelines
(Summary of Abstracts, December 21, 2018)
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Insulin Pumps for Patients with Any Diabetes Type: Clinical Effectiveness and Guidelines
(Summary of Abstracts, December 13, 2018)
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Pharmacotherapy Management of Type 2 Diabetes Mellitus: Guidelines
(Reference List, December 12, 2018)
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Preventative Foot Care for Patients with Diabetes: A Review of Clinical Effectiveness, Cost-Effectiveness, and Guidelines
(Summary with Critical Appraisal, November 14, 2018)
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Interventions for Malnutrition in Seniors: Clinical Effectiveness, Cost-Effectiveness, and Guidelines
(Summary of Abstracts, October 3, 2018)
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Foot Care Interventions for Adults in the Community Setting: Clinical Effectiveness and Guidelines
(Summary of Abstracts, July 20, 2018)
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Nutritional and Exercise Interventions for the Delayed Progression or Reversal of Frailty: Cost-Effectiveness
(Summary of Abstracts, June 8, 2018)
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Calcium and Vitamin D Supplementation for Adults: Safety and Guidelines
(Summary of Abstracts, June 7, 2018)
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Nutritional Interventions for the Delayed Progression or Reversal of Frailty: Clinical Effectiveness
(Summary of Abstracts, May 28, 2018)
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Flash Glucose Monitoring System for Diabetes
(Emerging Health Technologies, March 29, 2018)
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Drugs for Type 2 Diabetes: Second-Line Therapy Review Update
Short on time? Read the In Brief.
(Therapeutic Review, February 7, 2018) -
Newer Drugs for Type 2 Diabetes: An Emerging Adjunctive Therapy to Insulin for Type 1 Diabetes?
(Emerging Health Technologies, January 22, 2018)
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Protective Eyewear for Health Care Workers: Clinical Effectiveness and Guidelines
(Summary of Abstracts, October 19, 2020)
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Frequency of Eye Examinations: Guidelines
(Summary of Abstracts, October 4, 2019)
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Vasopressin for Vaginal Bleeding Following Miscarriage
(Summary of Abstracts, October 4, 2022)
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Self-Sampling Devices for HPV Testing
(Emerging Health Technologies, December 21, 2021)
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HPV Self-Sampling for Primary Cervical Cancer Screening: A 2021 Update
(Summary of Abstracts, September 7, 2021)
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HPV Testing for Primary Cervical Cancer Screening
(Summary of Abstracts, August 20, 2021)
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Routine Pelvic Examination for the Detection of Malignant or Benign Gynecological Conditions
(Reference List, July 13, 2021)
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Breast and Cervical Cancer Screening Recommendations for Transgender or Non-Binary Individuals
(Summary of Abstracts, March 23, 2021)
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Colorectal and Breast Cancer Screening for Survivors of Childhood, Adolescent, or Young Adult Cancers
(Summary of Abstracts, March 16, 2021)
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Vaginal Swabbing for the Diagnosis of Candidiasis or Bacterial Vaginosis
(Summary of Abstracts, February 3, 2021)
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Screening and Diagnostic Services for People at Risk of Breast Cancer: A Rapid Qualitative Review
(Summary with Critical Appraisal, October 31, 2019)
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HPV Testing for Primary Cervical Cancer Screening
Short on time? Read the In Brief.
(Optimal Use, July 8, 2019) -
Digital Tomosynthesis for the Screening and Diagnosis of Breast Cancer: Diagnostic Accuracy, Cost-Effectiveness, and Guidelines
(Summary of Abstracts, June 11, 2019)
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HPV Self-Sampling for Primary Cervical Cancer Screening: A Review of Diagnostic Test Accuracy and Clinical Evidence – An Update
Short on time? Read the In Brief .
(Summary with Critical Appraisal, May 30, 2019) -
Risk-Based Breast Cancer Screening versus Population-Based Breast Cancer Screening: A Review of the Comparative Clinical and Cost Effectiveness
(Summary with Critical Appraisal, January 5, 2018)
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Virtual Care Use in Primary Care or Specialty Care Settings
Short on time? Read the Report in Brief.
(Rapid Review, August 17, 2022) -
Improving Access to Primary Care in Canada
(Environmental Scan, July 19, 2022)
-
Melatonin for the Treatment of Insomnia in Children and Adolescents
(Rapid Review, June 10, 2022)
-
Behaviourally Based Interventions for Tobacco Smoking Prevention in Children and Adolescents
(Reference List, June 3, 2022)
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Melatonin for the Treatment of Insomnia: A 2022 Update
(Rapid Review, May 24, 2022)
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Medications Containing Low-dose Codeine for the Treatment of Pain and Coughs
(Rapid Review, August 20, 2021)
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Laxatives and Erectile Dysfunction Medications to Treat Side Effects of Opioid Agonist and Methadone Maintenance Therapy
(Rapid Review, June 22, 2021)
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Direct to Patient Virtual Visits
(Emerging Health Technologies, June 4, 2021)
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Electronic Aids to Daily Living
Short on time? Read the In Brief.
(Environmental Scan, May 6, 2021) -
2021 Health Technology Trends to Watch
(Roundup, February 4, 2021)
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Connected Devices to Support Remote Examination and Diagnosis in Primary Care and Specialty Care
(Emerging Health Technologies, December 10, 2020)
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Protective Eyewear for Health Care Workers: Clinical Effectiveness and Guidelines
(Summary of Abstracts, October 19, 2020)
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Needleless Injectors for the Administration of Vaccines: A Review of Clinical Effectiveness
(Summary with Critical Appraisal, July 17, 2020)
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Montelukast for Patients with Rhinitis or Chronic Urticaria: Clinical Effectiveness
(Reference List, July 14, 2020)
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Hand Sanitizer on Glove Exteriors: Clinical Effectiveness and Guidelines
(Reference List, July 14, 2020)
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Botulinum Toxin for Treating Primary Focal Hyperhidrosis in Adult Patients: Clinical Effectiveness
(Summary of Abstracts, July 13, 2020)
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Primary Care Initiated Gender-Affirming Therapy for Gender Dysphoria: A Review of Evidence Based Guidelines
(Summary with Critical Appraisal, May 1, 2020)
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Skin Preparation for Injections: A Review of Clinical Effectiveness, Cost-Effectiveness and Guidelines
(Summary with Critical Appraisal, April 16, 2020)
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Hand Washing for Patients: Clinical Effectiveness and Guidelines
(Summary of Abstracts, March 9, 2020)
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Smoking Cessation in Community Settings: Guidelines
(Summary of Abstracts, February 26, 2020)
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Nicotine Replacement Therapy for Vaping Cessation in Adults: Clinical Effectiveness
(Reference List, February 24, 2020)
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Lancets for Point of Care and Capillary Blood Testing: Guidelines
(Reference List, January 15, 2020)
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Bacteriophage Therapy for Treatment of Clostridioides difficile: Clinical Effectiveness and Guidelines
(Reference List, November 26, 2019)
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The Use of Medical Cannabis with Other Medications: A Review of Safety and Guidelines - An Update
(Summary with Critical Appraisal, September 27, 2019)
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Pharmacist-Led Interventions for Tobacco Smoking Cessation: A Review of Clinical Effectiveness and Cost-Effectiveness
(Summary with Critical Appraisal, September 9, 2019)
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Interventions for the Treatment and Management of Clostridioides Difficile: Clinical Effectiveness and Guidelines
(Reference List, August 14, 2019)
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Interventions for the Diagnosis of Clostridioides Difficile: Clinical Effectiveness and Guidelines
(Reference List, August 2, 2019)
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Interventions Used to Screen for Clostridioides Difficile: Clinical Effectiveness and Guidelines
(Reference List, July 29, 2019)
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Walkers with Wheels Versus Walkers Without Wheels for Fall Prevention in Older Adults: A Review of the Comparative Clinical Effectiveness
(Summary with Critical Appraisal, July 22, 2019)
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Frenectomy Techniques for Infants with Tongue and Lip Tie: Clinical Effectiveness
(Summary of Abstracts, May 16, 2019)
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Exercises and Massage Post-Frenectomy for Infants with Tongue and Lip Tie: Clinical Effectivenes
(Summary of Abstracts, May 14, 2019)
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Nonsteroidal Anti-Inflammatory Drugs and Hypertension: Safety
(Summary of Abstracts, January 24, 2019)
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Tongue and Lip Tie Cutting for Posterior Tongue Tie and Lip Tie: Clinical Effectiveness
(Summary of Abstracts, January 14, 2019)
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Use of Technology in Patient and Family Education: Clinical Effectiveness and Guidelines
(Summary of Abstracts, November 6, 2018)
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Benzydamine for Acute Sore Throat: A Review of Clinical Effectiveness and Guidelines
(Summary with Critical Appraisal, September 21, 2018)
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Requests and Referrals for Allergy Testing: Guidelines
(Summary of Abstracts, July 25, 2018)
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Rituximab Maintenance Therapy for the Treatment and Management of Rheumatoid Arthritis: A Review of Clinical Effectiveness
(Summary with Critical Appraisal, July 4, 2018)
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Rapid Tests for the Diagnosis of Group A Streptococcal Infection: A Review of Diagnostic Test Accuracy, Clinical Utility, Safety, and Cost-Effectiveness
(Peer-reviewed Summary with Critical Appraisal, May 31, 2018)
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Clinical Decision Rules and Strategies for the Diagnosis of Group A Streptococcal Infection: A Review of Clinical Utility and Guidelines
(Summary with Critical Appraisal, May 23, 2018)
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Drugs for the Management of Rheumatoid Arthritis
(Health Technology Assessment, April 25, 2018)
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Biosimilars — Regulatory, Health Technology Assessment, Reimbursement Trends, and Market Outlook
(Environmental Scan, January 19, 2018)
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Thermometer Use for Febrile Pediatric Patients: Clinical Effectiveness, Accuracy, and Guidelines
(Summary of Abstracts, January 19, 2018)
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Urethral Inserts for the Management of Adult Male Urinary Incontinence
(Rapid Review, April 16, 2021)
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Risk Calculators for Prostate Cancer: Clinical Utility and Guidelines
(Reference List, October 31, 2019)
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Floatation Therapy for Physical Conditions
(Rapid Review, January 10, 2022)
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Massage Therapy for Musculoskeletal Pain
(Summary of Abstracts, November 10, 2021)
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Hip Protectors for Community-Dwelling Older Adults
(Rapid Review, September 2, 2021)
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Bisphosphonate Drugs for the Treatment of Osteoporosis in Post-Menopausal Women
(Technology Review, June 1, 2021)
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Codeine for Pain Related to Osteoarthritis of the Knee and Hip: A Review of Clinical Effectiveness
(Summary with Critical Appraisal, December 14, 2020)
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Capsaicin for Acute or Chronic Non-Cancer Pain: A Review of Clinical Effectiveness, Safety, and Cost-Effectiveness
(Summary with Critical Appraisal, July 13, 2020)
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Capsaicin for Acute or Chronic Non-Cancer Pain: A Review of Guidelines
(Summary with Critical Appraisal, June 29, 2020)
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Acetaminophen for Chronic Pain in Pediatric Populations: Clinical Effectiveness
(Summary of Abstracts, June 8, 2020)
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Ketamine for Chronic Non-Cancer Pain: A Review of Clinical Effectiveness, Cost-Effectiveness, and Guidelines
(Summary with Critical Appraisal, June 2, 2020)
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Antidepressants for Chronic Pain in Pediatric Populations: Clinical Effectiveness
(Summary of Abstracts, May 25, 2020)
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External Supports for the Treatment of Ankle Sprain: A Review of Clinical Effectiveness
(Summary with Critical Appraisal, May 7, 2020)
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Nonsteroidal Anti-Inflammatory Drugs for Chronic Pain in Pediatric Populations: Clinical Effectiveness
(Summary of Abstracts, May 7, 2020)
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Gabapentinoids for Chronic Pain in Pediatric Populations: Clinical Effectiveness
(Summary of Abstracts, May 6, 2020)
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Pharmacological Interventions for Chronic Pain in Pediatric Patients: A Review of Guidelines
(Summary with Critical Appraisal, May 5, 2020)
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Exercise for the Treatment of Ankle Sprain: A Review of Clinical Effectiveness and Guidelines
(Summary with Critical Appraisal, April 13, 2020)
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Manual Therapy for Persistent, Non-Cancer Back and Neck Pain: A Review of Clinical Effectiveness
(Summary with Critical Appraisal, March 2, 2020)
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Physical Activity for Chronic Osteoarthritic Knee Pain: A Review of Clinical Effectiveness
(Summary with Critical Appraisal, February 17, 2020)
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Exercise for Chronic, Non-Cancer Back Pain: A Review of Cost-Effectiveness and Guidelines
(Summary with Critical Appraisal, November 12, 2019)
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Acupuncture for Chronic Non-Cancer Pain: A Review of Clinical Effectiveness, Cost Effectiveness and Guidelines
Short on time? Read the In Brief.
(Summary with Critical Appraisal, October 29, 2019) -
Physical Activity for Chronic Non-Cancer Knee Pain: Clinical Effectiveness, Cost-Effectiveness and Guidelines
(Reference List, October 22, 2019)
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Aerobic Exercise for Chronic Non-Cancer Back Pain: A Review of Clinical Effectiveness
(Summary with Critical Appraisal, October 16, 2019)
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Physical Therapist-Led Physical Activity for Chronic, Non-Cancer Knee Pain: Clinical Effectiveness, Cost-Effectiveness and Guidelines
(Reference List, October 15, 2019)
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Manual Therapy for Persistent or Chronic Non-Specific Back Pain: Clinical Effectiveness, Cost-Effectiveness and Guidelines
(Reference List, October 8, 2019)
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Duration of Bisphosphonate Treatment for Patients with Osteoporosis: A Review of Clinical Effectiveness and Guidelines
(Summary with Critical Appraisal, October 4, 2019)
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Strength-based Exercise for Chronic Non-Cancer Back Pain: A Review of Clinical Effectiveness
(Summary with Critical Appraisal, September 27, 2019)
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Manual Therapy for Persistent or Chronic Non-Specific Neck Pain: Clinical Effectiveness, Cost-Effectiveness and Guidelines
(Reference List, September 24, 2019)
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Custom-Made Foot Orthoses versus Prefabricated foot Orthoses: A Review of Clinical Effectiveness and Cost-Effectiveness
(Summary with Critical Appraisal, September 23, 2019)
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Mindfulness Training and Yoga for the Management of Chronic Non-malignant Pain: A Review of Clinical Effectiveness and Cost-effectiveness
(Summary with Critical Appraisal, September 20, 2019)
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Cognitive Behavioural Therapy for Chronic Non-Cancer Pain: A Review of Clinical Effectiveness
(Summary with Critical Appraisal, September 16, 2019)
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Orthotics Material for Patients Requiring Foot Orthotics: Clinical Effectiveness and Cost Effectiveness
(Summary of Abstracts, August 15, 2019)
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Medical Cannabis for the Treatment of Chronic Pain: A Review of Clinical Effectiveness and Guidelines
(Summary with Critical Appraisal, July 24, 2019)
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Yoga for Chronic Non-Malignant Pain Management: A Review of Clinical Effectiveness, Cost-Effectiveness and Guidelines
(Summary with Critical Appraisal, July 8, 2019)
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Mindfulness Training for Chronic Non-malignant Pain Management: A Review of the Clinical Effectiveness, Cost-effectiveness and Guidelines
Short on time? Read the In Brief.
(Summary with Critical Appraisal, June 25, 2019) -
Multidisciplinary Treatment Programs for Patients with Chronic Non-Malignant Pain: A Review of Clinical Effectiveness, Cost-effectiveness, and Guidelines – An Update
Short on time? Read the In Brief.
(Summary with Critical Appraisal, May 10, 2019) -
Tiered Care for Chronic Non-Malignant Pain: A Review of Clinical Effectiveness, Cost-Effectiveness, and Guidelines
(Summary with Critical Appraisal, February 12, 2019)
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Tramadol for the Management of Pain in Adult Patients: A Review of Clinical Effectiveness — An Update
(Summary with Critical Appraisal, November 16, 2018)
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Monoclonal Antibodies for Osteoarthritis of the Hip or Knee
(Emerging Health Technologies, July 11, 2018)
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Exercise Interventions for the Delayed Progression or Reversal of Frailty
(Summary of Abstracts, May 25, 2018)
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Gabapentin for Adults with Neuropathic Pain: A Review of the Clinical Effectiveness
(Summary with Critical Appraisal, March 12, 2018)
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Emerging Non-Opioid Drugs for the Treatment of Pain
(Environmental Scan, February 16, 2018)
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Intravenous Lidocaine for Chronic Pain: A Review of the Clinical Effectiveness and Guidelines
(Summary with Critical Appraisal, January 26, 2018)
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Internet-Delivered Cognitive Behavioural Therapy in the Treatment of Chronic Non-Cancer Pain
(Optimal Use, October 3, 2022)
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Osmotic-Controlled Release Methylphenidate for the Treatment of Attention-Deficit/Hyperactivity Disorder
(Summary of Abstracts, September 6, 2022)
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Guidelines for Pharmaceutical Treatment of Attention-Deficit/Hyperactivity Disorder
(Reference List, August 29, 2022)
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Patient Navigation Programs for People With Dementia
(Summary with Critical Appraisal, February 24, 2021)
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Non-invasive Nerve Stimulation Modalities for Migraine Pain: A Review of Clinical Effectiveness and Cost-effectiveness
(Summary with Critical Appraisal, April 27, 2020)
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Timely Treatment and Diagnosis of Adult Concussions: Clinical Effectiveness and Guidelines
(Summary of Abstracts, March 18, 2020)
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Lasmiditan for the Acute Treatment of Migraine
(Emerging Health Technologies, March 17, 2020)
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Medical Cannabis for the Treatment of Dementia: A Review of Clinical Effectiveness and Guidelines
(Summary with Critical Appraisal, July 17, 2019)
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Monoclonal antibodies to prevent migraine headaches
(Emerging Health Technologies, February 1, 2018)
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Cannabinoids for Behavioural Symptoms in Adults with Dementia: A Review of Clinical Effectiveness and Guidelines
(Summary with Critical Appraisal, January 5, 2018)
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Botulinum Toxin A for Chronic Migraines: Clinical Effectiveness
(Summary of Abstracts, January 3, 2018)
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Screening for Asymptomatic Bacteriuria During Pregnancy
(Reference List, July 18, 2022)
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Newborn Transcutaneous Bilirubin Screening: A 2022 Update
(Summary of Abstracts, February 4, 2022)
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Obstetrical Ultrasound During Pregnancy
(Rapid Review, December 16, 2021)
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Iron Isomaltoside for Anemia due to Pregnancy, Menorrhagia, or Other Gynecological Conditions
(Summary of Abstracts, December 3, 2021)
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Oxytocin Administration for Labour Induction and Augmentation
(Reference List, October 28, 2021)
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Prenatal and Postnatal Home Visiting Programs for Parents, Newborns, and Babies: A Review of Clinical Effectiveness, Cost-Effectiveness, and Guidelines
(Summary with Critical Appraisal, February 26, 2020)
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Screening and Treatment of Obstetric Anemia: A Review of Clinical Effectiveness, Cost-Effectiveness, and Guidelines
(Summary with Critical Appraisal, December 6, 2019)
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Caesarean Delivery for Pregnancies in the First Stage of Labor: Clinical Effectiveness and Guidelines
(Summary of Abstracts, September 9, 2019)
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Post-operative Procedures for Caesarean Sections: A Review of Clinical Effectiveness and Guidelines
(Summary with Critical Appraisal, July 29, 2019)
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Craniosacral Therapy for Mothers and Infants with Breastfeeding Issues: Clinical Effectiveness
(Summary of Abstracts, May 23, 2019)
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Buprenorphine for Opioid Use Disorders during Pregnancy: A Review of Comparative Clinical Effectiveness, Safety, Cost-Effectiveness, and Guidelines
Short on time? Read the In Brief.
(Summary with Critical Appraisal, May 9, 2019) -
Ulipristal versus Levonorgestrel for Emergency Contraception: A Review of Comparative Cost Effectiveness
Short on time? Read the In Brief.
(Summary with Critical Appraisal, February 12, 2019) -
Ulipristal versus Levonorgestrel for Emergency Contraception: A Review of Comparative Clinical Effectiveness and Guidelines
(Summary with Critical Appraisal, October 29, 2018)
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Peer Support Programs for Youth Mental Health
(Health Technology Assessment, November 8, 2022)
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Guidelines for Treatment of Alcohol Withdrawal in Outpatient Settings
(Summary of Abstracts, October 14, 2022)
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Clinical Effectiveness of Opioid Substitution Treatment
Short on time? Read the In Brief.
(Rapid Review, January 10, 2022) -
Physical activity and support programs for mild/moderate major depressive disorder: A Reference List
(Reference List, December 3, 2021)
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Remote Substance-Monitoring Devices and Mobile Applications for Substance Use Disorders
(Summary of Abstracts, November 15, 2021)
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Harm Reduction Interventions to Prevent Overdose
(Policy Insight, August 5, 2021)
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Psychedelic-Assisted Psychotherapy for Post-Traumatic Stress Disorder, Anxiety Disorders, Mood Disorders, or Substance Use Disorders
(Rapid Review, June 25, 2021)
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Artificial Intelligence and Machine Learning in Mental Health Services: A Literature Review
(Rapid Review, June 14, 2021)
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Treatment Programs for Substance Use Disorder
(Summary with Critical Appraisal, June 8, 2021)
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Strategies for the Reduction or Discontinuation of Opioids: A 2021 Update
(Summary of Abstracts, May 11, 2021)
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Pharmacological and Non-Pharmacological Vaping Cessation Interventions for Youth
(Reference List, May 4, 2021)
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Substance and Nicotine Cessation Interventions for People with Problematic Substance Use
(Summary of Abstracts, April 13, 2021)
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Gabapentin, Phenobarbital, Diazepam, and Lorazepam for the Treatment of Alcohol Withdrawal: Clinical Effectiveness and Guidelines
(Summary of Abstracts, June 24, 2020)
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Injectable Opioid Agonist Treatment for Patients with Opioid Dependence: A Review of Clinical and Cost-Effectiveness
(Summary with Critical Appraisal, June 2, 2020)
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Non-pharmacological and Pharmacological Intervention for Smoking Cessation Programs in Youth: A Review of Clinical Effectiveness and Guidelines
(Summary with Critical Appraisal, March 2, 2020)
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Peer Support Interventions for Mental Health Conditions and Addictive Disorders: Clinical Effectiveness, Cost-Effectiveness, and Guidelines
(Summary of Abstracts, February 17, 2020)
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Group-Based Eating Disorder Treatment Program for Binge Eating Disorder: Clinical Effectiveness and Guidelines
(Summary of Abstracts, December 3, 2019)
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Canine and Equine Therapy for Mental Health: A Review of Clinical Effectiveness
(Rapid Review, August 30, 2019)
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Bright Light Therapy for Depression: Clinical Effectiveness
(Summary of Abstracts, August 28, 2019)
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Benzodiazepines for the Treatment of Adults with Mental Health Conditions or Sleep Disorders Guidelines
(Summary of Abstracts, August 27, 2019)
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Internet-Delivered Cognitive Behavioural Therapy for Major Depressive Disorder and Anxiety Disorders: A Health Technology Assessment
Short on time? Read the In Brief.
(Optimal Use, July 22, 2019) -
Treatment for Methamphetamine Addiction: A Review of Guidelines
(Summary with Critical Appraisal, July 2, 2019)
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Opioid Agonist Treatments for Opioid Use Disorders: A Rapid Qualitative Review
(Summary with Critical Appraisal, April 30, 2019)
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Buprenorphine for Opioid Use Disorder: A Review of Comparative Clinical Effectiveness, Safety, Cost-Effectiveness, and Guidelines
Short on time? Read the In Brief.
(Summary with Critical Appraisal, April 24, 2019) -
Nabilone for the Treatment of Post-Traumatic Stress Disorder: A Review of Clinical Effectiveness and Guidelines
(Summary with Critical Appraisal, February 20, 2019)
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Interventions for Insomnia Disorder
Short on time? Read the In Brief.
(Report, December 10, 2018) -
Internet-Based Cognitive Behavioral Therapy for Post-Traumatic Stress Disorder: A Review of Clinical Effectiveness
(Peer-reviewed Summary with Critical Appraisal, November 26, 2018)
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Guided Versus Unguided Internet-Delivered Cognitive Behavioural Therapy for Major Depressive Disorder and Anxiety Disorders: Comparative Clinical Effectiveness
(Summary of Abstracts, October 29, 2018)
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e-Therapy Interventions for the Treatments of Substance Use Disorders and Other Addictions: A Review of Clinical Effectiveness
(Summary with Critical Appraisal, June 27, 2018)
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e-Therapy Interventions for the Treatment of Post-Traumatic Stress Disorder: Clinical Evidence
(Summary with Critical Appraisal, June 13, 2018)
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Internet-based Brief Interventions for Substance Misuse in Youth and Young Adults: A Review of Clinical Effectiveness, Cost-Effectiveness and Guidelines
(Summary with Critical Appraisal, June 7, 2018)
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e-Therapy Interventions for the Treatment of Anxiety: Clinical Evidence
(Summary with Critical Appraisal, May 31, 2018)
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e-Therapy Interventions for the Treatments of Patients with Depression: A Review of Clinical Effectiveness
(Summary with Critical Appraisal, May 18, 2018)
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Alternative Practitioners and Treatments for Mental Health Conditions: Clinical and Cost-Effectiveness and Guidelines
(Summary of Abstracts, April 25, 2018)
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Telehealth for the Assessment and Treatment of Depression, Post-Traumatic Stress Disorder, and Anxiety: Clinical Evidence
(Summary with Critical Appraisal, April 10, 2018)
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Antidepressants for Adults with Depression using Opioid Medications: Clinical Effectiveness and Guidelines
(Summary of Abstracts, February 16, 2018)
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Management of Acute Anxiety in the Pre-Hospital Setting: Guidelines
(Summary of Abstracts, February 8, 2018)
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Tuberculosis Screening for People with Chronic Conditions
(Summary with Critical Appraisal, May 13, 2021)
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Diagnosis, Management, and Re-assessment of Obstructive Sleep Apnea in Adults
(Summary of Abstracts, April 9, 2021)
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Positive Airway Pressure and Oral Appliances for the Treatment of Obstructive Sleep Apnea in Adults
(Summary of Abstracts, April 5, 2021)
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Lung Cancer Screening: Clinical Utility and Guidelines
(Reference List, October 13, 2020)
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Prevention Strategies for Recurrent Tuberculosis: Guidelines
(Summary of Abstracts, August 31, 2020)
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Montelukast for Patients with Asthma: Clinical Effectiveness
(Reference List, August 4, 2020)
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Bacille Calmette-Guérin Vaccination: A Review of Clinical Effectiveness and Guidelines
(Summary with Critical Appraisal, April 6, 2020)
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Masks for Prevention of Influenza Transmission in Acute and Long-Term Care Settings: A Review of Clinical Effectiveness, Cost-Effectiveness and Guidelines
(Summary with Critical Appraisal, March 31, 2020)
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Asthma Treatments for Acute Asthma in Pediatric Patients: Clinical Effectiveness, Cost Effectiveness, and Guidelines
(Summary of Abstracts, February 26, 2020)
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Interventions for the Treatment or Management of Tuberculosis: Clinical Effectiveness and Guidelines
(Reference List, July 8, 2019)
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Interventions for the Diagnosis of Tuberculosis: Clinical Effectiveness and Guidelines
(Reference List, July 2, 2019)
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Fluoroquinolones for the Treatment of Other Respiratory Tract Infections: A Review of Clinical Effectiveness, Cost-Effectiveness, and Guidelines
(Summary with Critical Appraisal, May 31, 2019)
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High Dose Influenza Vaccine for Adults: A Review of Clinical Effectiveness, Cost-Effectiveness, and Guidelines
(Summary with Critical Appraisal, January 8, 2019)
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Pulmonary Function Testing: Guidelines
(Summary of Abstracts, May 30, 2018)
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Newer Biologics for the Treatment of Plaque Psoriasis
(Rapid Review, September 23, 2021)
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Adalimumab for Adult Patients with Plaque Psoriasis: A Review of Clinical Effectiveness
(Summary with Critical Appraisal, June 22, 2020)
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Oral Antibiotics versus IV Antibiotics for Patients with Cellulitis or Soft Tissue Infections: Clinical Effectiveness and Guidelines
(Summary of Abstracts, December 11, 2019)
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Ivermectin for Parasitic Skin Infections of Lice: A Review of Comparative Clinical Effectiveness, Cost-Effectiveness, and Guidelines
(Rapid Review, May 14, 2019)
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Hyaluronic Acid Injection for Facial Grooves or Wrinkles: Clinical Effectiveness, Safety, and Guidelines
(Summary of Abstracts, March 14, 2019)
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Topical Cantharidin/ Salicylic Acid/ Podophyllin for the Treatment of Warts: Clinical Effectiveness and Guidelines
(Reference List, January 21, 2019)
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Emollient Treatments for Atopic Dermatitis: A Review of Clinical Effectiveness, Cost-Effectiveness, and Guidelines
(Rapid Review, January 14, 2019)
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Clinical Tests for Diagnosis of Scabies: Diagnostic Accuracy, Clinical Effectiveness, Cost Effectiveness, and Guidelines
(Summary of Abstracts, December 19, 2018)
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Honey for Wound Management: A Review of Clinical Effectiveness and Guidelines
(Rapid Review, November 6, 2018)
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Cyclosporine for Moderate to Severe Plaque Psoriasis in Adults: A Review of Clinical Effectiveness and Safety
(Rapid Review, April 3, 2018)
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A Noncultured Autologous Skin Cell Spray Graft for the Treatment of Burns
(Emerging Health Technologies, March 13, 2018)
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Natural Sheepskins for Prevention or Treatment of Pressure Ulcers: Clinical Effectiveness. Cost-Effectiveness, and Guidelines
(Summary of Abstracts, December 8, 2017)
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Behaviourally Based Interventions for Vaping Prevention in Children and Adolescents
(Reference List, June 10, 2022)
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Peer Support Programs for Adults Who Have Experienced Sexual Assault, Abuse, Harassment, or Misconduct: A Review of Clinical Effectiveness and Guidelines
(Summary with Critical Appraisal, November 16, 2017)
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Assessing and Managing Chronic Non-Cancer Pain
(Tools, November 30, 2021)
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Artificial Intelligence in Mental Health Services: A Summary of a Literature Review
This summary tool summarizes findings from a literature review that evaluated the published evidence on artificial intelligence (AI) for the prevention, diagnosis, and treatment of mental health illnesses. It also summarizes findings on the clinical effectiveness of AI applications, purpose of use, patient populations, primary users, and related evidence-based guidelines.
(Tools, August 17, 2021) -
Codeine for Pain: A Synopsis of the Evidence
A summary of the evidence (based on a number of CADTH reviews) on codeine for pain.
(Tools, July 29, 2021) -
Non-Opioid Options for Managing Pain
To help support decisions about managing pain, CADTH has been reviewing the evidence on different treatment options for various types of pain. Here, you’ll find the highlights of many of these evidence reviews.
(Tools, September 21, 2020) -
Acute Pain Management: Non-Pharmacological Interventions
Over the last few years, CADTH has been asked to review, the clinical effectiveness evidence and the recommendations from evidence-based guidelines for treating various acute pain conditions with non-pharmacological interventions. Here, you’ll find the evidence highlights related to those evidence reviews.
(Tools, September 17, 2020) -
Non-Drug Ways to Manage Chronic Pain
Resources for people living with chronic pain and resources for clinicians.
(Tools, September 8, 2020) -
Evaluating the Credibility of Health Websites: Can You Trust Dr. Google?
Tips and resources for determining whether a health website contains reliable health information
(Tools, March 25, 2020) -
Evidence Highlights: HPV Testing for Primary Cervical Cancer Screening
Highlights from the CADTH Optimal Use project that assessed the clinical effectiveness, cost-effectiveness, patients’ perspectives and experiences, ethical considerations, and implementation issues associated with HPV testing for primary cervical cancer screening.
(Tools, October 7, 2019) -
Internet-Delivered Cognitive Behavioural Therapy for Major Depression and Anxiety Disorders
Evidence Highlights
(Tools, July 22, 2019) -
Prevention and Treatment of Diabetic Foot Ulcers: A Synopsis of the Evidence
A summary of the evidence (based on a number of CADTH reviews) on various approaches to preventing and treating diabetic foot ulcers.
(Tools, June 24, 2019) -
Publicly Funded and Managed Naloxone Programs in Canada
This two-page, quick-reference map provides information on publicly funded take-home naloxone programs for the provinces, territories, and federal drug plans. This tool also outlines what naloxone is, who is at risk of an opioid overdose, and what can be found in a take-home naloxone kit.
(Tools, April 23, 2019) -
Opioid Prescribing and Pain Management: Prescription Monitoring Program Overview and the Management of Acute Low Back Pain
CADTH partnered with the New Brunswick Department of Health, New Brunswick Medical Society, and Choosing Wisely New Brunswick to create this module on opioid prescribing. The module provides an overview of the New Brunswick Prescription Monitoring Program and addresses the management of acute low back pain.
(Tools, March 6, 2019) -
Gabapentin for Adults With Neuropathic Pain: A Review
A summary of five CADTH reports, published between 2014 and 2018, on gabapentin for neuropathic pain.
(Tools, February 27, 2019) -
Alternatives to Proton Pump Inhibitors
Provides suggested lifestyle modifications and basic management strategies for GI conditions in an easy-to-print, one-page handout.
(Tools, September 3, 2018) -
Accessing Mental Health Outside of a Therapist’s Office: iCBT for Major Depression and Anxiety Disorders
On November 27, 2019, CADTH hosted a national Evidence to Action event to introduce evidence reviews led by CADTH and Health Quality Ontario and to discuss the use and implementation of internet-delivered cognitive behavioural therapy (iCBT) for major depression and anxiety disorders in Canada. In the event, Karilyn Xu (student at York University and iCBT user) , Dr. David Gratzer (Psychiatrist at the Centre for Addiction and Mental Health, and Associate Chief of the General Adult Psychiatry and Health Systems Division), Patrick Mitchell (Director of the Mental Health and Addictions Policy, Accountability and Provincial Partnership at the Ontario Ministry of Health), and Dr. Heather Hadjistavropoulos (Professor in the Department of Psychology at the University of Regina and Founder and Director of the Online Therapy Unit in Saskatchewan) shared their perspectives on using and implementing iCBT for these conditions in Canada.
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Managing crystal meth withdrawal: It’s not crystal clear
Hospital News Article (November 19, 2019)
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Psychedelic-assisted psychotherapy: Should we alter our perception of psychedelics for clinical use?
(Hospital News article, October 6, 2021)
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Thinking beyond medications for chronic pain management
(Hospital News article, May 2022)
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Overused and low-value: What to leave behind after COVID-19
(Hospital News article, August 26, 2021)
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Considering the place of codeine in the treatment of osteoarthritis pain
(Hospital News article, June 2, 2021)
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Non-Pharmacological Interventions for Chronic Non-Cancer Pain: The Science of Mindfulness
(Webinar, November 1, 2019)
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Cervical cancer screening: Is it time for a new test?
Hospital News Article (May 1, 2019)
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Rapid tests for the diagnosis of Streptococcal infections: Viable alternative or sorely overrated?
Hospital News Article (September 4, 2018)
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Developments in diabetes management: What do we know about tirzepatide?
(Hospital News article, July 2022)
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What we know about new technologies for managing diabetes (and don’t)
(Hospital News article, June 30, 2021)
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Urinary Dipstick Testing for Bladder Cancer Screening: Diagnostic Accuracy, Clinical Effectiveness and Guidelines
(Summary of Abstracts, April 1, 2019)
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Point-of-Care Urine Dipstick Testing for Suspected Urinary Tract Infections for Adults: Diagnostic Accuracy
(Reference List, February 15, 2019)
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Fosfomycin for Lower Urinary Tract Infections: Comparative Clinical and Cost-Effectiveness
(Summary of Abstracts, April 12, 2018)
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Intravesical Botulinum Toxin for Adults with Non-Neurogenic Bladder Conditions: A Review of Clinical Effectiveness, Cost-Effectiveness and Guidelines
(Summary with Critical Appraisal, March 15, 2018)