Last Updated : June 19, 2015
Details
FilesProject Line:
Health Technology Review
Project Sub Line:
Summary with Critical Appraisal
Project Number:
RC0673-000
Question
- What is the clinical effectiveness of proton pump inhibitors for the treatment and prevention of gastrointestinal conditions?
- What is the comparative clinical effectiveness of proton pump inhibitors for the treatment and prevention of gastrointestinal conditions?
- What is the cost-effectiveness of proton pump inhibitors for the treatment of gastrointestinal conditions?
- What is the comparative cost-effectiveness of proton pump inhibitors for the treatment of gastrointestinal conditions?
Key Message
Overall, PPIs are reported to be more effective than placebo or H2 receptor antagonists (H2RAs) for resolution of symptoms associated with GERD and to improve healing of esophagitis. However, PPIs were not found to be effective for the relief of GERD-related cough in both adults and children, and the use of PPIs in infants is associated with adverse events. PPIs were reported to be more cost-effective that H2RAs, placebo, or no treatment. The evidence on cost-effectiveness between PPIs and surgery was inconsistent. No consistent differences were reported on the effectiveness of one PPI versus another, and therefore it was reported that the least costly PPI is likely to be the most cost-effective, especially for long-term therapy.
Files
Last Updated : June 19, 2015