Evidence for Optimizing the Use of Lab Tests
Whether you’re a clinician deciding which test to order for your patient, a laboratory professional, or a policy-maker seeking credible information, here you can find independent evidence on medical laboratory tests to help you in your role.
We've selected the following materials to get you started:
- Folate Testing in People With Suspected Folate Deficiency (Rapid Review, March 28, 2022)
- Emerging Multi-Cancer Early Detection Technologies (Health Technology Update, April 22, 2022)
- Vitamin B12 Testing in People with Suspected Vitamin B12 Deficiency (Rapid Review, March 24, 2022)
- Pharmacogenomic Testing in Depression: A 2021 Update (Rapid Review, January 18, 2022)
- Self-Sampling Devices for HPV Testing (Emerging Health Technologies, December 21, 2021)
- Interferon Gamma Release Assay for the Identification of Latent Tuberculosis Infection in Rural and Remote Settings (Summary With Critical Appraisal, April 9, 2021)
- Rapid Testing for the Diagnosis of Pulmonary Tuberculosis and Rifampicin Resistance: A Review of Cost-Effectiveness (Summary With Critical Appraisal, February 19, 2021)
In this Bundle
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Interferon Gamma Release Assay for the Identification of Latent Tuberculosis Infection in Rural and Remote Settings
(Summary with Critical Appraisal, April 9, 2021)
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Antinuclear Antibody Testing for Systemic Lupus Erythematosus or Connective Tissue Disease
(Summary of Abstracts, January 26, 2021)
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Rheumatoid Factor and Anti-cyclic Citrullinated Peptide Testing for Arthralgia: Diagnostic Accuracy, Clinical Utility, and Guidelines
(Summary of Abstracts, November 26, 2020)
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Interferon Gamma Release Assay for the Identification of Latent Tuberculosis Infection in People with Previous Bacille Calmette-Guérin Vaccination: Clinical Utility, Cost-Effectiveness, and Guidelines
(Summary of Abstracts, August 31, 2020)
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Interferon Gamma Release Assay for the Identification of Latent Tuberculosis Infection in Rural and Remote Settings: Clinical Utility, Cost-Effectiveness, and Guidelines
(Summary of Abstracts, August 17, 2020)
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Biomarker-Based Point-of-Care Tests for the Evaluation of Mild Traumatic Brain Injury
(Emerging Health Technologies, June 23, 2020)
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Creatinine and Urea Point of Care Testing for Patients with Suspected Renal Failure: Clinical Utility, Cost-Effectiveness and Guidelines
(Summary of Abstracts, April 20, 2020)
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Natriuretic Peptide Testing for Monitoring of Heart Failure Therapy: A Review of Clinical Effectiveness, Clinical Utility, Cost-Effectiveness, and Guidelines
(Summary with Critical Appraisal, August 19, 2019)
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Natriuretic Peptide Testing for Perioperative Risk Assessment: Clinical Effectiveness, Cost-Effectiveness, and Guidelines
(Summary of Abstracts, July 31, 2019)
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Natriuretic Peptide Testing for Pulmonary Arterial Hypertension: Clinical Effectiveness, Cost-Effectiveness, and Guidelines
(Summary of Abstracts, July 24, 2019)
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Sample Selection for Biomarker Testing in Adults with Breast Cancer: Guidelines
(Summary of Abstracts, February 6, 2019)
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Rheumatoid Factor Testing: Guidelines
(Summary of Abstracts, July 23, 2018)
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Self-Sampling Devices for HPV Testing
(Emerging Health Technologies, December 21, 2021)
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Anal Cancer Screening in High Risk Populations: Clinical Effectiveness, Diagnostic Accuracy, Cost-Effectiveness, and Guidelines
(Summary of Abstracts, September 20, 2019)
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Fecal Occult Blood Testing in Acute Care Settings: A Review of Clinical Utility
(Summary with Critical Appraisal, September 5, 2019)
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HPV Testing for Primary Cervical Cancer Screening
Short on time? Read the In Brief.
(Optimal Use, July 8, 2019) -
Blood Culture Frequency in Febrile Pediatric In-patients: Clinical Effectiveness, Cost-Effectiveness, and Guidelines
(Reference List, June 11, 2019)
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HPV Self-Sampling for Primary Cervical Cancer Screening: A Review of Diagnostic Test Accuracy and Clinical Evidence – An Update
Short on time? Read the In Brief .
(Summary with Critical Appraisal, May 30, 2019) -
Occult Blood Detection Testing for Non-Colorectal Cancer Related Medical Conditions: Clinical Effectiveness
(Reference List, April 15, 2019)
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Screening for Chlamydia trachomatis and Neisseria gonorrhoeae During Pregnancy: A Health Technology Assessment
(Health Technology Assessment, November 22, 2018)
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HPV Self-Sampling for Primary Cervical Cancer Screening: A Review of Diagnostic Test Accuracy and Clinical Evidence
(Summary with Critical Appraisal, April 19, 2018)
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Folate Testing in People With Suspected Folate Deficiency
(Rapid Review, March 28, 2022)
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Vitamin B12 Testing in People with Suspected Vitamin B12 Deficiency
(Rapid Review, March 24, 2022)
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Maximum Blood Draw for Pediatric Patients
(Summary of Abstracts, March 4, 2022)
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Newborn Transcutaneous Bilirubin Screening: A 2022 Update
(Summary of Abstracts, February 4, 2022)
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International Normalized Point of Care Testing for Patients on Anticoagulant Therapies: Clinical Utility and Cost-Effectiveness
(Summary of Abstracts, April 27, 2020)
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Troponin I Point of Care Testing for Patients with Suspected Acute Coronary Syndrome or Myocardial Infarction: Clinical Utility, Cost-Effectiveness and Guidelines
(Summary of Abstracts, March 31, 2020)
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Screening and Treatment of Obstetric Anemia: A Review of Clinical Effectiveness, Cost-Effectiveness, and Guidelines
(Summary with Critical Appraisal, December 6, 2019)
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Interventions for the Diagnosis of Lyme Disease: Clinical Effectiveness and Guidelines
(Reference List, July 12, 2019)
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Frequency of Complete Blood Counts for Patients at Risk of Heparin-Induced Thrombocytopenia:
(Summary with Critical Appraisal, October 2, 2018)
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Optimal Strategies for the Diagnosis of Acute Pulmonary Embolism
Short on time? Read the In Brief
(Optimal Use, March 1, 2018) -
Frequency of Prothrombin Time and International Normalized Ratio Testing: Guidelines
(Summary of Abstracts, January 17, 2018)
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Transcutaneous Bilirubin Measurements in Newborns: Clinical and Cost-Effectiveness, and Guidelines
(Summary of Abstracts, November 21, 2017)
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Point-Of-Care D-Dimer Testing: A Review of Diagnostic Accuracy, Clinical Utility, and Safety
(Summary with Critical Appraisal, November 14, 2017)
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Rapid Testing for the Diagnosis of Pulmonary Tuberculosis and Rifampicin Resistance: A Review of Cost-Effectiveness
(Summary with Critical Appraisal, February 19, 2021)
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Vaginal Swabbing for the Diagnosis of Candidiasis or Bacterial Vaginosis
(Summary of Abstracts, February 3, 2021)
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Screening Triage Tools and Management Algorithms for Adult Sepsis Patients: Clinical Utility and Guidelines
(Reference List, August 13, 2019)
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Interventions for the Diagnosis of Clostridioides Difficile: Clinical Effectiveness and Guidelines
(Reference List, August 2, 2019)
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Detection and Diagnosis of Sepsis in Rural and Remote Areas: An Environmental Scan
(Environmental Scan, January 9, 2019)
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Rapid Tests for the Diagnosis of Group A Streptococcal Infection: A Review of Diagnostic Test Accuracy, Clinical Utility, Safety, and Cost-Effectiveness
(Peer-reviewed Summary with Critical Appraisal, May 31, 2018)
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Recognition and Diagnosis of Sepsis in Adults: Evidence-Based Guidelines
(Summary of Abstracts, January 24, 2018)
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Recognition and Diagnosis of Sepsis in Rural or Remote Areas: Clinical and Cost-Effectiveness and Guidelines
(Reference List, January 23, 2018)
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An Overview of Comprehensive Genomic Profiling Technologies to Inform Cancer Care
(Emerging Health Technologies, August 10, 2022)
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Pharmacogenomic Testing in Depression: A 2021 Update
(Rapid Review, January 18, 2022)
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Rapid Testing for the Diagnosis of Pulmonary Tuberculosis and Rifampicin Resistance: A Review of Cost-Effectiveness
(Summary with Critical Appraisal, February 19, 2021)
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Dihydropyrimidine Dehydrogenase Testing for Fluoropyrimidine Toxicity
(Summary of Abstracts, February 5, 2021)
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Rapid and Simultaneous Tuberculosis and Antibiotic Susceptibility Testing for the Diagnosis of Pulmonary Tuberculosis and Rifampicin Resistance: A Review of Diagnostic Accuracy
(Summary with Critical Appraisal, December 10, 2020)
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Rapid and Simultaneous Tuberculosis and Antibiotic Susceptibility Testing for the Diagnosis of Pulmonary Tuberculosis and Rifampicin Resistance: Diagnostic Accuracy and Cost-Effectiveness
(Summary of Abstracts, June 29, 2020)
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Saliva-Based Tests to Detect Active Severe Acute Respiratory Syndrome Coronavirus 2 Infection
(Health Technology Update, June 3, 2020)
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Circulating Tumour DNA Testing for the Identification of Genetic Mutations: Diagnostic Test Accuracy and Clinical Utility
(Reference List, February 24, 2020)
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Pharmacogenomic Testing in Depression: A Review of Clinical Effectiveness, Cost-Effectiveness, and Guidelines
(Summary with Critical Appraisal, February 18, 2020)
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Genome-Wide Sequencing: Ethical Considerations
(Technology Review, November 12, 2019)
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Rapid Genome-wide Testing: A Review of Clinical Utility, Cost-Effectiveness, and Guidelines
(Summary with Critical Appraisal, September 20, 2019)
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Non-invasive fetal RHD genotyping: A Rapid Qualitative Review
(Summary with Critical Appraisal, June 27, 2019)
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Genome-Wide Sequencing for Unexplained Developmental Delays and Multiple Congenital Anomalies: A Rapid Qualitative Review
Short on time? Read the In Brief
(Summary with Critical Appraisal, May 16, 2019) -
Gene Expression Tests for Women with Early Stage Breast Cancer: A Review of Clinical Utility and Cost-Effectiveness
(Summary with Critical Appraisal, October 16, 2017)
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Computerized Provider Order Entry Systems for Laboratory and Diagnostic Tests: Clinical Effectiveness, Cost-Effectiveness, and Guidelines
(Summary of Abstracts, November 2, 2020)
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Identification of Tuberculosis: A Review of the Guidelines
(Summary with Critical Appraisal, March 18, 2020)
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Interventions Used to Screen for Tuberculosis: Clinical Effectiveness and Guidelines
(Reference List, June 24, 2019)
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Requests and Referrals for Allergy Testing: Guidelines
(Summary of Abstracts, July 25, 2018)
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Point of Care Testing: An Environmental Scan
(Environmental Scan, October 4, 2017)
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Emerging Multi-Cancer Early Detection Technologies
(Health Technology Update, April 22, 2022)
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Magnetic Localization System for Sentinel Lymph Node Biopsy: A Review of the Diagnostic Accuracy, Cost-Effectiveness, and Guidelines
(Summary with Critical Appraisal, March 2, 2020)
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Biopsy for Adults with Suspected Skin Cancer: A Rapid Qualitative Review
(Summary with Critical Appraisal, November 21, 2019)
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An Overview of Liquid Biopsy for Screening and Early Detection of Cancer
(Report, November 14, 2019)
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Evidence Highlights: HPV Testing for Primary Cervical Cancer Screening
Highlights from the CADTH Optimal Use project that assessed the clinical effectiveness, cost-effectiveness, patients’ perspectives and experiences, ethical considerations, and implementation issues associated with HPV testing for primary cervical cancer screening.
(Tools, October 7, 2019) -
Genome-wide sequencing for developmental delay: What’s next for families after a genetic diagnosis?
Hospital News article
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Screening for Asymptomatic Bacteriuria During Pregnancy
(Reference List, July 18, 2022)
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Urinary Dipstick Testing for Bladder Cancer Screening: Diagnostic Accuracy, Clinical Effectiveness and Guidelines
(Summary of Abstracts, April 1, 2019)
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Screening for Chlamydia trachomatis and Neisseria gonorrhoeae During Pregnancy: A Health Technology Assessment
(Health Technology Assessment, November 22, 2018)
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Point-of-Care Urine Testing for Suspected Urinary Tract Infections in the Emergency Department: Diagnostic Accuracy, Clinical Utility, and Guidelines
(Summary of Abstracts, December 12, 2017)
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Point-of-Care Urine Pregnancy Screening in the Emergency Department: Diagnostic Accuracy, Clinical Utility, and Guidelines
(Summary of Abstracts, December 7, 2017)
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Point-of-Care Testing for Influenza
(Emerging Health Technologies, November 3, 2016)